Development and Larval Morphology of Loa loa in Experimental Primate Hosts

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Abstract
Experimental infections with L. loa were established in laboratory primates [Papio anubis Erythrocebus patas] by inoculation of 3rd-stage larvae recovered from either Chrysops silacea infected after engorging on a human volunteer with loiasis or C. atlanticus infected after blood feeding on experimentally infected primates. The 3rd molt occurred at 16-20 days potinoculation of infective larvae and the 4th at about 50 days. Early larval development was characterized by rapid growth and marked differentiation of the reproductive systems. Differences in the body''s growth rate between the sexes were seen as early as 30 days and were especially marked by 60 days. Females grew more rapidly and for a longer time than males. Males reach maximum size by 120 days, females not until about 300 days. Female worms were inseminated prior to day 90, developing eggs filled the uteri by 120 days and microfilariae appeared in the peripheral blood at .apprx. 150 days. Morphological features of the larval and adult stages of human L. loa are described.

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