2-Acetylaminofluorene induces forms of cytochrome P-450 active in its own metabolism
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 3 (6) , 711-713
- https://doi.org/10.1093/carcin/3.6.711
Abstract
The effect of short-term treatment of rats with 2-acetyl-aminofluorene on the metabolism of this same compound by liver microsomes has been investigated. This treatment was found to increase the formation of 7-, 9-, and N-hydroxy-2-acetyiaminofluorene 3–4 fold. The largest effect was seen in the formation of 5- and 3-hydroxy-2-acetylaminofluorene, which increased 105- and 27.3-foM, respectively. There was no significant increase in the formation of 1-hydroxy-2-acetylaminofluorene.This publication has 4 references indexed in Scilit:
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