Clinical and Bacteriological Results in Urinary Tract Infections with Single-Dose Ro 13–9904 (Rocephin®)
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 27 (1) , 80-92
- https://doi.org/10.1159/000238034
Abstract
In two studies, the therapeutic effect of a single intramuscular dose of Ro 13-9904 (Rocephin®) of 500 or 250 mg, respectively, was compared with a single intramuscular dose of 80 mg tobramycin in chronic urinary tract infections. 7 days after 500 mg Ro 13-9904, the infections were eradicated in 10 of the 11 patients; 7 days after 250 mg Ro 13-9904, 4 of 11 patients were reinfected with selected resistant Streptococcus faecalis. After tobramycin, 9 of 23 patients were cured. Considering enterococci as dangerous organisms in several respects we recommend a single dose of 500 mg Ro 13-9904 with a satisfactory local tolerance. Tobramycin is unsuitable for single-dose treatment.Keywords
This publication has 1 reference indexed in Scilit:
- Ro 13-9904, a long-acting broad-spectrum cephalosporin: in vitro and in vivo studiesAntimicrobial Agents and Chemotherapy, 1980