One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze

1 February 1990

journal article
research article
Published by Springer Nature in Psychopharmacology

Vol. 100 (2) , 281-282
https://doi.org/10.1007/bf02244419

Abstract

Chlordiazepoxide (CDP 7.5 mg/kg) had a significant anxiolytic effect in rats tested on the plus-maze for the first time. On a second trial the control scores did not change, but those of the CDP group did and they no longer differed from controls. Rats previously tested undrugged or after flumazenil (4 mg/kg) also failed to show an anxiolytic response to CDP. Thus this phenomenon of one-trial tolerance depended on prior experience with the plus-maze. It also depended on CDP acting at the benzodiazepine receptors on trial 2, since the joint administration of CDP and flumazenil on trial 2 reversed the phenomenon.

This publication has 3 references indexed in Scilit:

Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance
Brain Research Bulletin, 1987
The use of a plus-maze to measure anxiety in the mouse
Psychopharmacology, 1987
Tolerance to the behavioral actions of benzodiazepines
Neuroscience & Biobehavioral Reviews, 1985