Induction of Cell Killing, Micronuclei, and Mutation to 6-Thioguanine Resistance after Exposure to Low-Dose-Rate γ Rays and Tritiated Water in Cultured Mammalian Cells (L5178Y)

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Abstract
Cell killing and induction of micronuclei and mutation to 6-thioguanine resistance were studied in growing cultured mammalian cells (L5178Y) after exposure for a fixed period to low-dose-rate γ rays and tritiated water (HTO) at comparable dose rates, from about 10 to 40 rad/hr. From the analysis of dose-response relationships, RBE values of HTO β rays relative to γ rays were calculated. These were 1.5 for cell killing, 2.0 for micronuclei, and 1.8 for mutation induction. Reported RBE values for HTO were reviewed.