The transformations of 4‐heteroarylaminomethylene‐5(4H)‐oxazolones into dehydropeptide derivatives
- 1 September 1995
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 32 (5) , 1605-1611
- https://doi.org/10.1002/jhet.5570320533
Abstract
2‐Phenyl‐4‐heteroarylaminomethylene‐5(4H)‐oxazolones 3, which were prepared from the corresponding N,N‐dimethyl‐N'‐heteroarylformamidines 1 and hippuric acid 2 in acetic anhydride, react with amino acids giving dehydropeptide derivatives 4, 5, and 6 as products. Dehydration of N‐protected peptides 7–10, containing glycine at the C‐terminal, followed by the reaction with formamidines 1 gave 2‐substituted‐4‐heteroarylaminomethylene‐5(4H)‐oxazolones 11–14.Keywords
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