Characterization of Four Amino Acids Constituting Cyl-2, a Metabolite from Cylindrocladium scoparium

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Abstract
A biologically active metabolite designated Cyl-2 from a phytopathogenic fungus, Cylindrocladium scoparium, was found to be composed of four amino acid residues, which fully account for all of the atoms constituting Cyl-2. These amino acids were identified as L-pipecolic acid, L-isoleucine, D-O-methyltyrosine and 2-amino-8-oxo-9, 10-epoxydecanoic acid. Thus, Cyl-2 was established as a cyclotetrapeptide containing novel amino acid residues.

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