ERYTHROBLASTIC ISLAND MACROPHAGE CULTURES - ROLE OF CULTURE SUPERNATANT IN RAT ERYTHROPOIESIS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 25  (1) , 17-22
Abstract
The isolation of central macrophages from erythroblastic islands (EI) permitted analysis of the role of EI macrophage factors in erythropoiesis. EI macrophage supernatant and peritoneal macrophage supernatant both had a similar effect on erythropoiesis. They exerted an erythropoietin-like effect. Changes were observed in the number of erythroblasts per island; their distribution within each island during the maturation process was described. The role of the central macrophage in EI was discussed. A direct transfer of an erythropoietin-like activity to the erythroblasts was suggested which increases the efficacy of stimulation.