Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet
Open Access
- 1 August 1999
- journal article
- Published by Oxford University Press (OUP) in American Journal of Hypertension
- Vol. 12 (8) , 826-829
- https://doi.org/10.1016/s0895-7061(98)00231-3
Abstract
To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and daily urine collection. High-fat diet induced a progressive increase in body weight (+47%) and a rapid rise in mean arterial pressure, heart rate, and glomerular filtration rate that stabilized, respectively, at 14%, 31% and 68% greater than control values. Time-course analysis of changes in blood pressure may reveal two components of obesity-induced hypertension, an early phase related to HFD itself and a later phase related to weight gain. Am J Hypertens 1999;12:826–829 © 1999 American Journal of Hypertension, Ltd.Keywords
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