Morphine Tolerance in Genetically Selected Rats Induced by Chronically Elevated Saccharin Intake
- 26 August 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4613) , 871-873
- https://doi.org/10.1126/science.6879185
Abstract
Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharine solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharine intake may cause increased release and utilization of endogenous opiates.Keywords
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