EFFECTIVE RABIES TREATMENT IN EXPOSED MONKEYS - A SINGLE DOSE OF INTERFERON INDUCER AND VACCINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 57  (5) , 807-813
Abstract
Rhesus monkeys were injected with lethal doses of rabies virus and then treated with a variety of treatment combinations. The most successful was 1 dose of an interferon inducer [poly(I)-poly(C)] complexed to poly-L-lysine and CM-cellulose and 1 dose of human diploid rabies vaccine. This combination proved as effective as hyperimmune serum and vaccine and much better than vaccine alone. The combination of the interferon inducer plus vaccine could be administered at least up to 48 h after the very severe challenge given and still provide marked protection.