Occlusion of the central vein of the retina is a serious disease. Opinions on its treatment have continued to differ, and the results achieved are far from always satisfactory. This, notwithstanding the fact that an important etiological factor of the pathogenesis of this disease, viz., arteriosclerosis, has been and still is the subject of lively research. Anticoagulant therapy was introduced in 1937 for occlusion of the central retinal vein.10 It proved beneficial.4,13,17,18,22,24,25 However, anticoagulants, heparin and bishydroxycoumarin (Dicumarol), were found to be incapable of improving the prognosis of the disease as regards either vision or secondary glaucoma.2 Material This is a comparative study of the experience gained at the Ophthalmic Clinic of the University of Helsinki in 1951-1956. The material consists of 81 retinal venous occlusions in 75 unselected patients who consulted the clinic for therapy. Various therapeutic methods have been tried at our clinic against thrombosis.