Evidence for the Existence of a Sensitizing Factor to Pressor Agents in the Plasma of Hypertensive Patients

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Abstract
The effect of plasma obtained from normotensive and hypertensive subjects on the changes of pressor response to angiotensin and norepinephrine was studied utilizing nephrectomized rats. Peripheral venous plasma from normotensive individuals when injected iv into the animals did not affect the sensitivity of the animal to either angiotensin or to norepinephrine. In contrast, when the same amount of peripheral plasma obtained from hypertensive patients was injected into these animals, it significantly increased the vascular sensitivity to both angiotensin and norepinephrine. The rise in sensitivity to either angiotensin or norepinephrine was greater with plasma from essential hypertensives with suppressed renin, followed by plasma from patients with malignant hypertension, renovascular hypertension, and essential hypertension without suppressed renin. Renal venous plasma from the ischemic kidney of patients with renovascular hypertension significantly increased the sensitivity to both pressor agents as compared to renal venous plasma from the normal kidney or the inferior vena cava of these patients. Along with the rise in sensitivity to the pressor agents, there was a rise of the mean arterial blood pressure of the animal. It is suggested that the plasma of hypertensive patients contains a factor or factors, probably of renal origin, which raises the blood pressure as well as the vascular sensitivity to pressor agents such as angiotensin and norepinephrine

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