One-Pot Synthesis of Glucosamine Oligosaccharides
- 29 December 2001
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (2) , 281-283
- https://doi.org/10.1021/ol017054d
Abstract
Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synthesis in a one-pot manner. One-pot sequential glycosylation of three and four units of 2-amino-2-deoxy glucose gave trisaccharides and tetrasaccharide in 50−81% yields.Keywords
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