Experimental Arthrosis: Early Changes in Synovial Morphology and Lysosomal Enzyme Activities

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Abstract
The Hulth procedure was used to induce osteoarthrosis in a knee joint in 36 rabbits, whereupon changes in chondral and synovial morphology and lysosomal enzyme activities are studied over a period of 3 mo. A significant increase in enzyme activities was observed, which was more pronounced and seemed to occur earlier in the synovial membrane than in the cartilage. Synovial morphological changes were conspicuous in an early stage of the disease process and also seemed to precede the changes in chondral morphology. The synovial membrane may be important in the pathogenesis of osteoarthrosis.