INHIBITION OF IODIDE OXIDATION BY THYROXINE AND OTHER ANTIOXIDANTS
- 1 September 1959
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 45 (9) , 1379-1382
- https://doi.org/10.1073/pnas.45.9.1379
Abstract
The oxidations of iodide H2O2 with or without catalyst (peroxidase) is inhibited by a number of organic compounds including selected hetero-cyclic compounds, thyroxine, and its relatives. Their high inhibitory efficiency suggests that these compounds function as antioxidants. The evidence presented together with independent observations support a hypothesis that antioxidant activity derives from the donor properties of systems with nonbonding and/or pi-orbital electrons. A consideration of the inhibition of iodide oxidation itself leads to the proposal that thyroid hormone output may be coupled to formation of its organoiodine precursors as a regulatory feedback system.This publication has 1 reference indexed in Scilit:
- ELECTRON-DONOR AND -ACCEPTOR PROPERTIES OF BIOLOGICALLY IMPORTANT PURINES, PYRIMIDINES, PTERIDINES, FLAVINS, AND AROMATIC AMINO ACIDSProceedings of the National Academy of Sciences, 1958