RHYTHMIC CHANGES IN DUODENAL MOTILITY ASSOCIATED WITH GASTRIC PERISTALSIS

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Abstract
In dogs prepared with cannulated gastric and duodenal fistulas, simultaneous graphic records of gastric peristalsis, pyloric activity and duodenal motility show that: During digestion as the gastric peristaltic wave approaches the pylorus there is, regularly, marked inhibition of the rhythmic contractions of the first 15 or 20 cm. of the duodenum. Recovery of activity in the duodenum begins at the same time as the contraction of the pyloric sphincter that follows each gastric wave. The changes descr. start at the pylorus and travel downward at a speed characteristic of the spread of descending inhibition (10 cm. per sec.) but more rapidly than ordinary peristalsis. Records of the activity of the duodenum between antral cycles do not resemble records of intestinal peristalsis. The gastric influence appears, on the whole, to diminish the activity of the part of the duodenum affected as compared to the activity of other unaffected parts. The duodenum is inhibited along with the stomach while food is beins taken. The authors agree with Joseph and Meltzer that there is a receptive relaxation of the duodenum associated with each gastric peristaltic wave, but are unable to detn. whether the subsequent contraction is in part due to the passage of the gastric wave over the pylorus or entirely to recovery of the duodenum from inhibition.

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