Gene therapy for high grade gliomas
- 1 March 2001
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Biological Therapy
- Vol. 1 (2) , 239-252
- https://doi.org/10.1517/14712598.1.2.239
Abstract
High grade gliomas in adults are devastating diseases, with very poor survival despite their lack of distant metastases. Local treatments, such as surgical resection and stereotactic radiosurgery, have been most successful, whereas systemic therapy (for example, chemotherapy and immunotherapy) have been rather disappointing. Several gene therapy systems have been successful in controlling or eradicating these tumours in animal models and are now being tested as a logical addition to current clinical management. This review describes the gene therapy clinical protocols that have been completed or that are ongoing for human gliomas. These include the prodrug activating system, herpes simplex thymidine kinase (HSVtk)/ganciclovir (GCV), utilising either retrovirus vector producer cells or adenovirus vectors; adenovirus mediated p53 gene transfer; adenovirus mediated IFN-β gene transfer and oncolytic herpes virus and adenovirus vectors. To date, all of the clinical studies have used direct injection of the vec...Keywords
This publication has 47 references indexed in Scilit:
- A Phase 1-2 Clinical Trial of Gene Therapy for Recurrent Glioblastoma Multiforme by Tumor Transduction with the Herpes Simplex Thymidine Kinase Gene Followed by GanciclovirHuman Gene Therapy, 1999
- Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cellsCancer Gene Therapy, 1999
- Molecular Evaluation of Biopsy and Autopsy Specimens from Patients Receiving in Vivo Retroviral Gene TherapyHuman Gene Therapy, 1999
- A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent GlioblastomaHuman Gene Therapy, 1998
- Biosafety Monitoring of Patients Receiving Intracerebral Injections of Murine Retroviral Vector Producer CellsHuman Gene Therapy, 1998
- Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other MeansNeurosurgery, 1998
- Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cellsNature Medicine, 1997
- Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomasThe Lancet, 1995
- Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.Proceedings of the National Academy of Sciences, 1994
- Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.The Journal of Experimental Medicine, 1992