INTERFERON INCREASES IGE BINDING TO BASOPHILS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 50  (5) , 305-308
Abstract
One of the pivotal manifestations of immediate type hypersensitivity is mediator release from a variety of mediator cells, e.g., mast cells and basophils. The essential step of this process is the binding of IgE to the surface of these cells. The influence of human interferon (IFN) on the binding of IgE to human leukocytes (basophils) was examined. Pre-treatment of leukocytes (basophils) with different types of IFN leads to a pronounced increase in binding of IgE to these cells. The data support the hypothesis concerning a pathogenetic role of IFN in the development of allergy of the immediate type hypersensitivity.