Sodium Transport and D.C. Resistance in the Isolated Toad Skin in Relation to Shedding of the Stratum Corneum

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Abstract
It has been assumed that the main resistance to sodium ion movements is located in the superficial layer of the amphibian skin. It is therefore of interest to follow transport function during shedding of the stratum corncum. Shedding of the stratum corneum in the isolated toad skin (Bufo bufo) can be induced by aldosterone treatment of skin from hypophysectornized toads. It is shown that slough formation is followed by an almost three fold increase in short‐circuit current. This increase is accounted for by an increased rate of active sodium transport and is preceded by an increase in passive sodium permeability and a decrease in D.C. resistance. The results are discussed in relation to the functional organization of the skin, and to moulting in vivo.