Degradation of chromosomal DNA during apoptosis
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Open Access
- 1 January 2003
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 10 (1) , 108-116
- https://doi.org/10.1038/sj.cdd.4401161
Abstract
Apoptosis is often accompanied by degradation of chromosomal DNA. CAD, caspase-activated DNase, was identified in 1998 as a DNase that is responsible for this process. In the last several years, mice deficient in the CAD system have been generated. Studies with these mice indicated that apoptotic DNA degradation occurs in two different systems. In one, the DNA fragmentation is carried out by CAD in the dying cells and in the other, by lysosomal DNase II after the dying cells are phagocytosed. Several other endonucleases have also been suggested as candidate effectors for the apoptotic degradation of chromosomal DNA. In this review, we will discuss the mechanism and role of DNA degradation during apoptosis.Keywords
This publication has 103 references indexed in Scilit:
- Identification of a factor that links apoptotic cells to phagocytesNature, 2002
- DNA Fragmentation Factor 45 Mutant Mice Exhibit Resistance to Kainic Acid-Induced Neuronal Cell DeathBiochemical and Biophysical Research Communications, 2001
- Lack of Obvious 50 Kilobase Pair DNA Fragments in DNA Fragmentation Factor 45-Deficient Thymocytes upon Activation of ApoptosisBiochemical and Biophysical Research Communications, 2000
- Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitorJournal of Molecular Biology, 2000
- Multiple Domains of DFF45 Bind Synergistically to DFF40: Roles of Caspase Cleavage and Sequestration of Activator Domain of DFF40Biochemical and Biophysical Research Communications, 1999
- Study of DFF45 in Its Role of Chaperone and Inhibitor: Two Independent Inhibitory Domains of DFF40 Nuclease ActivityBiochemical and Biophysical Research Communications, 1999
- Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with ApoptosisJournal of Biological Chemistry, 1998
- Cytosolic Nuclease Activated by Caspase-3 and Inhibited by DFF-45Biochemical and Biophysical Research Communications, 1998
- Apoptosis by Death FactorCell, 1997
- Programmed Cell Death in Animal DevelopmentCell, 1997