QUANTIFICATION OF ANGIOGENESIS ON THE RAT AORTIC RING ASSAY
Open Access
- 1 March 2003
- journal article
- Published by Slovenian Society for Stereology and Quantitative Image Analysis in Image Analysis and Stereology
- Vol. 22 (1) , 43-48
- https://doi.org/10.5566/ias.v22.p43-48
Abstract
Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total number of branching, the maximal microvessel length and the number of microvessels in function of the distance to the aortic ring; (3) the total number of isolated fibroblast-like cells and the number of fibroblast-like cells in function of the distance to the aortic ring. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by vascular endothelial growth factor (VEGF).Keywords
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