ELEVATED SERUM-CALCIUM CONCENTRATIONS IN MAMMARY-TUMOR BEARING C3H-FG MICE WITHOUT BONY METASTASES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 28  (1) , 34-37
Abstract
Sera from 8 adult C3H/Fg mice bearing spontaneous mammary gland tumors were analyzed for Ca content in 2 successive weekly samples. Sera from 6 mice had significantly elevated serum Ca concentrations while sera from 2 were normocalcemic. I.m. implantation of mammary gland tumors into 12, 3 mo. old female C3H/Fg mice resulted in significant and progressive increases in serum Ca concentrations over a 4 wk period. S.c. implants had a similar effect, but gave less consistent results. These data supported the hypothesis that mammary gland tumors are capable of inducing elevated serum Ca concentrations in C3H/Fg mice. Low grade elevation of serum Ca occasionally seen in adult female C3H/Fg mice may be caused by incipient mammary gland tumors.

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