7-N-Amidinocephalosporins
- 1 June 1975
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 18 (6) , 627-630
- https://doi.org/10.1021/jm00240a023
Abstract
7-Aminocephalosporanic acid tert-butyl ester reacts quantitatively at--20 degrees with iminium chlorides to give amidino derivatives. Removal of the tert-butyl protecting group with trifluoroacetic acid and treatment with 1 equiv of triethylamine yield the corresponding zwitterions. These compounds were less active than their penicillin analogs.Keywords
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