Concentration and Secretion of Gastric Somatostatin in Streptozotocin-diabetic Rats
- 1 March 1981
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 30 (3) , 188-191
- https://doi.org/10.2337/diab.30.3.188
Abstract
Both the release and the content of gastric somatostatin were investigated in streptozotocin-diabetic rats. Fundic and antral somatostatin contents were both increased in streptozotocin-diabetic rats compared with control animals. Basal somatostatin levels in the perfusates of streptozotocin-treated animals were not significantly different from those of the control animals. However, the peak values of somatostatin release induced by 5 × 10−9 M glucagon in the diabetic animals were significantly higher than those of the controls. These results lead us to conclude that a hyperfunctioning state of the gastric D-Cells exists in hypoinsulinemic diabetes.Keywords
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