Childhood Acromegaly: Successful Therapy with Conventional Radiation and Effects of Chlorpromazine on Growth Hormone and Prolactin Secretion1

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Abstract
A pre-adolescent girl with gigantism is described in whom growth hormone, insulin, prolactin, thyrotropin and triiodothyronine measurements have been performed prior to conventional radiation therapy. An acute and chronic (62 days) trial and evaluation of chlorpromazine failed to decrease growth hormone or increase prolactin concentrations. Radiation therapy was associated with a prompt return to normal levels of fasting growth hormone concentrations 3 months following 5000 rad administration. A lack of fall in growth hormone levels while on chlorpromazine therapy suggests that chronic treatment with this drug is ineffective. Conventional x-ray therapy in this patient with childhood acromegaly was effective and may be the treatment of choice when non-invasive therapy is indicated.

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