Role of Calcium in Complement Dependent Hemolysis.
- 1 October 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 117 (1) , 179-181
- https://doi.org/10.3181/00379727-117-29529
Abstract
Summary The cation requirements of two complement dependent hemolytic systems, one involving red cells from patients with paroxysmal nocturnal hemoglobinuria, and the other involving antibody coated sheep red cells, are similar when studied in undiluted human serum as a source of complement. Both are inhibited by the presence of Na3HEDTA, but not by Na2Mg EDTA. These results suggest that the need for Ca+ + in complement dependent hemolysis is not absolute, while the need for Mg++ is.Keywords
This publication has 2 references indexed in Scilit:
- Biologic Properties of Polynucleotides. IV. Studies on the Mechanism of Complement Inhibition by Polyinosinic Acid Together with Observations on the In Vivo Effect of Polyinosinic Acid on Complement Activity*Journal of Clinical Investigation, 1964
- CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIESThe Journal of Experimental Medicine, 1963