Effects of Chloral Hydrate, γ‐Butyrolactone, and Equithesin on the Efflux of Dopamine and 5‐Hydroxytryptamine Metabolites into Cerebroventricular Perfusates of Rats
- 1 July 1982
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 39 (1) , 235-238
- https://doi.org/10.1111/j.1471-4159.1982.tb04724.x
Abstract
Chloral hydrate, .gamma.-butyrolactone and equithesin are general anesthetics which have been employed in a variety of neurochemical and electrophysiological experiments. The effects of these anesthetics on the efflux of dopamine and 5-hydroxytryptamine metabolites into lateral cerebroventricular perfusates were determined in rats bearing chronically implanted cannulas. Chloral hydrate and equithesin increased, whereas .gamma.-butyrolactone decreased, the efflux of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid. None of the anesthetics had a consistent effect on the efflux of the 5-hydroxytryptamine metabolite 5-hydroxyindoleacetic acid.Keywords
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