Do transmembrane protein superfolds exist?
- 27 February 1998
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 423 (3) , 281-285
- https://doi.org/10.1016/s0014-5793(98)00095-7
Abstract
A reliable and widely used transmembrane protein structure prediction algorithm was applied to five representative genomic sequence data sets in order to re-examine the hypothesis that in contrast to globular proteins there are no favored transmembrane protein fold families. When the number of predicted membrane spanning segments and the topology of these segments is taken into account then definite biases are observed which suggest that certain transmembrane topologies are significantly more common than others.Keywords
This publication has 11 references indexed in Scilit:
- CATH – a hierarchic classification of protein domain structuresPublished by Elsevier ,1997
- Protein structural classes in five complete genomesNature Structural & Molecular Biology, 1997
- Are there dominant membrane protein families with a given number of helices?Proteins-Structure Function and Bioinformatics, 1997
- Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracyProtein Science, 1996
- Topology prediction of membrane proteinsProtein Science, 1996
- Membrane protein anchors and polytopic determinantsBiochemical Society Transactions, 1995
- Peptides in membranes: Helicity and hydrophobicityBiopolymers, 1995
- Protein superfamilles and domain superfoldsNature, 1994
- A Model Recognition Approach to the Prediction of All-Helical Membrane Protein Structure and TopologyBiochemistry, 1994
- Predicting the topology of eukaryotic membrane proteinsEuropean Journal of Biochemistry, 1993