Abstract
Two primary human adenoid cystic carcinomas of skin were studied histologically and histochemically. Histologically, they closely resembled adenoid cystic carcinoma found in other tissues but in the skin, they must be distinguished from aggressive basal cell carcinomas. The natural history of these tumors and those collected from the literature suggest a long indolent and progressive course. Local excision with meticulous histologic control of the surgical margins appears to be an appropriate therapeutic strategy. Lymph node metastases were not observed.

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