Quinidine for Prophylaxis of Arrhythmias in Acute Myocardial Infarction

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Abstract
The efficacy of quinidine therapy for the prevention of cardiac arrhythmias was determined in a prospective controlled clinical trial involving 53 patients with uncomplicated acute myocardial infarction. After a loading procedure, 300 mg of quinidine sulfate or placebo was administered orally every six hours for five days under balanced, random, double-blind conditions. An automated arrhythmia detection system was used to quantify arrhythmias from stored continuous electrocardiographic tape recordings.