L-Asparaginase Induced Immunosuppression: Inhibition of Bone Marrow Derived Antibody Precursor Cells

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Abstract
The cooperation between bone marrow and thymus cells in restoring the hemolytic antibody response to sheep erythrocytes in immunosuppressed recipients was markedly inhibited when donor mice were treated with L-asparaginase, a known inhibitor of lymphocyte function. The marrow cell population was shown to be a major target for the immunosuppressive activity of asparaginase, since thymus cells from enzyme-treated animals interacted with marrow cells from normal animals to generate immunocompetent cells.