Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
- 1 January 1997
- book chapter
- Published by Springer Nature
- Vol. 79, 233-269
- https://doi.org/10.1007/978-3-0348-9006-9_10
Abstract
Vascular permeability factor (VPF), variously known as a vascular endothelial growth factor (VEGF) and vasculotropin (VAS), is a multifunctional cytokine with important roles in vasculogenesis and both pathological and physiological angiogenesis. Originally described in the late 1970s as a tumor-secreted protein that potently increased microvascular permeability to plasma proteins, VPF/VEGF (as we will designate the molecule in this review) exerts a variety of effects on vascular endothelial cells which together promote the formation and growth of new blood vessels. Thus, in addition to rendering microvessels hyperpermeable, VPF/VEGF stimulates endothelial cells to migrate and divide and profoundly alters their pattern of gene expression.Keywords
This publication has 158 references indexed in Scilit:
- Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cellsPublished by Elsevier ,2004
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumNature, 1995
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Biological Activity and Phosphorylation Sites of the Bacterially Expressed Cytosolic Domain of the KDR VEGF-ReceptorBiochemical and Biophysical Research Communications, 1994
- Cobalt Stimulates the Expression of Vascular Endothelial Growth Factor mRNA in Rat Cardiac CellsBiochemical and Biophysical Research Communications, 1994
- Synthesis and Secretion of Vascular Permeability Factor/Vascular Endothelial Growth Factor by Human Retinal Pigment Epithelial CellsBiochemical and Biophysical Research Communications, 1993
- Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor ReceptorsBiochemical and Biophysical Research Communications, 1993
- Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factorBiochemical and Biophysical Research Communications, 1992
- AIDS-associated kaposi's sarcoma cells in culture express vascular endothelial growth factorBiochemical and Biophysical Research Communications, 1992
- Glycosylation of vascular endothelial growth factor is not required for its mitogenic activityBiochemical and Biophysical Research Communications, 1992