Effectiveness of Drug Therapy in Hypertension: Present Status

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Abstract
Progress in the development of effective antihypertensive agents is briefly reviewed. Evidence that drug treatment reduces the incidence of major complications is presented. The recently completed controlled trial carried out in Veterans Administration hospitals indicates that in men with diastolic blood pressure levels of 90 through 114 mm Hg the risk of developing a morbid event over a five-year period was reduced from 55% to 18% by treatment. The degree of benefit was proportional to the risk, which in turn was related directly to the level of blood pressure.

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