Effect of Gentamicin on Human Blood Cells Metabolism as Measured by Microcalorimetry
- 1 May 1987
- journal article
- research article
- Published by SAGE Publications in Human Toxicology
- Vol. 6 (3) , 223-226
- https://doi.org/10.1177/096032718700600309
Abstract
The effect of gentamicin on overall metabolism in human blood cells was studied by microcalorimetry. At concentrations above therapeutic levels, the drug induced an increase in heat production rate in red cells, whereas no effect was found at lower concentrations. The Na/K-pump was unaffected at any gentamicin concentration. A slight increase in heat production rate was noted in granulocytes when incubated with gentamicin at concentrations above therapeutic levels, otherwise no effect was recorded at lower concentrations. Lymphocytes were unaffected by gentamicin at any concentration. Microcalorimetry seems to be a suitable method for studying the effect of drugs on overall cell metabolism, and for evaluating the Na/K-pump activity.This publication has 11 references indexed in Scilit:
- Effects of aminoglycoside antibiotics on polymorphonuclear leukocyte function in vivoAntimicrobial Agents and Chemotherapy, 1985
- Erythrocyte heat production in human obesity: Microcalorimetric investigation of sodium-potassium pump and cell metabolismMetabolism, 1985
- Clinical and Path ophysiologic Aspects of Aminoglycoside NephrotoxicityAmerican Journal of Kidney Diseases, 1982
- Gentamicin nephrotoxicity I. Acute biochemical correlates in ratsToxicology and Applied Pharmacology, 1981
- Gentamicin in 1978Annals of Internal Medicine, 1978
- Suppression of lymphocyte responses by cephalosporinsInfection and Immunity, 1978
- Calorimetry as an Analytical Tool in Biochemistry and BiologyPublished by Wiley ,1976
- A New Method for Separation of Human Blood ComponentsNature New Biology, 1973
- Ototoxicity of GentamicinThe Journal of Infectious Diseases, 1969