Marek's Disease Virus-Induced Tumor Transplants: Development and Rejection in Various Genetic Strains of Chickens

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Abstract
The ability of chicken strains of varied genetic resistance to Marek''s disease (MD) to resist or regress local and general reactions to transplantable tumor cells induced by several MD virus strains and to transmissible lymphoid tumor cells (Olson''s TLT) induced by an avian leukosis-sarcoma retrovirus was compared. MD virus infection alone could induce progressive tumors at the site of inoculation. Progression or regression of transplant tumors was independent of genetic susceptibility to MD. Incidence of virus-induced host tumors depended on genetic susceptibility to MD.