Die Wirkung von Pepsin auf Insulin und seine Acetylderivate. 4. Mitteilung über Insulin.

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Abstract
The present study, based on 1600 experiments with rabbits, tested the effect of pH, temp., duration of action and amount of enzyme on destruction of the insulin. From these experiments, as well as the fact that it proved impossible to reactivate the insulin by change of pH or storage for 1 to several days at various temp., it appears that the action is a typical protein digestion and not an adsorption. It is uncertain whether the insulin is a protein or whether it becomes unstable after destruction of some protein. The almost inactive acetyl insulin is attacked more slowly by pepsin; but regeneration is similar to that of insulin itself. Administered per os to pancreatectomized dogs, these 2 acetyl derivatives were inaffective.

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