TRANSFER OF NATURAL-RESISTANCE TO MAREKS-DISEASE (JMV) WITH NON-IMMUNE SPLEEN-CELLS .2. FURTHER CHARACTERIZATION OF PROTECTING CELL-POPULATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 125  (2) , 715-718
Abstract
Spleen cells from 8 wk old, nonimmunized donor chickens can transfer resistance to a supralethal dose of the [chicken] JMV leukemia cell line of Marek''s disease (MD) to newly hatched, highly susceptible, histocompatible recipients. The population of cells transferring resistance was previously shown to be non-T, non-B, and nonmacrophage in nature. Heavily x-irradiated spleen cells were unable to protect recipients from leukemia challenge. Both complement receptor-bearing and -lacking cells could confer resistance to newly hatched recipients. Fc receptor-bearing cells conferred significant protection to recipients; spleen cells depleted of Fc receptor-bearing cells were unable to protect chickens from death after JMV challenge. This indicates that the population of spleen cells, which is moderately radiosensitive and which possesses Fc receptors, is responsible for the transfer of natural resistance to the malignancy in vivo.

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