Vascular occlusion and infarction in sickle cell crisis and the sickle chest syndrome.

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Abstract
A young adult with homozygous sickle cell anemia (Hb SS) suffered a fatal sickle cell crisis complicated by the sickle chest syndrome. At necropsy multiple large infarcts of the lung, bone marrow and pituitary gland were found. The large majority of pulmonary infarcts were not associated with either gross or microscopic vaso-occlusion. These findings are discussed and correlated with past and current opinions of sickle cells crisis and the sickle chest syndrome.