Pharmacokinetic approach to the clinical use of lidocaine intravenously
- 19 July 1976
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 236 (3) , 273-277
- https://doi.org/10.1001/jama.236.3.273
Abstract
The time course of lidocaine [an antiarrhythmic drug] plasma concentrations following various modes of administration to patients were predicted by computer. Initiating therapy with a single i.v. bolus dose was unsatisfactory; plasma levels during the 1st h were potentially toxic after a 200 mg bolus and subtherapeutic after a 50-100 mg bolus. After 2 bolus doses of 100 mg, separated by 20-30 min, or a rapid loading infusion over 15-60 min, therapeutic concentrations were achieved and maintained. Pharmacokinetic principles can be of value in devising rational approaches to lidocaine dosage.This publication has 1 reference indexed in Scilit:
- Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in HumansAnnals of Internal Medicine, 1973