ISOLATION OF KANAMYCIN AND PAROMAMINE INACTIVATED BY E. COLI CARRYING R FACTOR
- 1 January 1968
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 21 (1) , 22-29
- https://doi.org/10.7164/antibiotics.21.22
Abstract
Kanamycin and paromamine were inactivated in the presence of ATP and Mg++ by an enzyme solution obtained from E. coli carrying R factor. The inactivated kanamycin was isolated and it was found that the hydroxyl group on C-3 of 6-amino-6-deoxy-D-glucose moiety was phosphorylated. In the inactivated paromamine, the hydroxyl group on C-3 of D-glucosamine moiety was phosphorylated. Besides the inactivated kanamycin above described, another inactivated kanamycin containing phosphate was isolated, though it is not certain that this is the product of enzymatic inactivation.Keywords
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