Localization of Two Genetic Factors to Different Areas of γ-Globulin Molecules
- 15 June 1962
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 136 (3520) , 979-980
- https://doi.org/10.1126/science.136.3520.979
Abstract
Gm(a) and Gm(b) factors are present in 7S γ-globulin molecules and absent in 19S γ-globulins, β2A-globulins and Bence-Jones proteins, whereas the Inv(b) factor was demonstrated in all four kinds of proteins. The Inv type was identical in isolated 7S and 19S γ-globulins of six normal sera. After papain splitting of 7S γ-globulin, Gm determining sites were present only in the fast (F) split product and Inv determining sites were present only in the slow (S).Keywords
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