ENHANCEMENT OF RAT BRAIN METABOLISM OF A TRYPTOPHAN LOAD BY CHRONIC ETHANOL ADMINISTRATION
Open Access
- 1 January 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 68 (1) , 22-24
- https://doi.org/10.1111/j.1476-5381.1980.tb10694.x
Abstract
We have previously shown that chronic ethanol administration enhances brain 5-hydroxytryptamine synthesis by increasing the availability of circulating tryptophan to the brain secondary to the decreased liver tryptophan pyrrolase activity. We now find that ethanol enhances the brain metabolism of a tryptophan load by the same mechanism. The results are discussed in relation to ethanol preference and the need for further clinical work on the effects of alcoholism on tryptophan metabolism.Keywords
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