Effect of Anti-Inflammatory Agents on Spontaneous Cure of Trichinella and Trichuris in Mice

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Abstract
Steroidal anti-inflammatory drugs (hydrocortisone or dexametha-sone) and nonsteroidal antiinflammatory drugs (indomethacin or phenylbutazone) were administered to mice infected with Trichinella spiralis or Trichuris muris. Treatment was begun several days after inoculation and continued until "spontaneous cure" had occurred in the untreated mice. Both steroids suppressed the loss of trichinella, whereas neither nonsteroid did so. The single steroid (hydrocortisone) used in Trichuris infections was highly effective in suppressing the loss of worms, while the single nonsteroid (indomethacin) was weakly, but significantly, effective. The data cannot be interpreted fully in the absence of supporting histological studies, but it is suggested that mucosal inflammation may play a minor role in the abrupt loss of the species of worms from the mouse host, and that corticosteroid drugs may suppress this loss by virtue of their immunosuppressive action.

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