Characterization of an antibody to the integrin β3 subunit (GP IIIa) from a patient with neonatal thrombocytopenia and an inherited deficiency of GP IIb-IIIa complexes in platelets (Glanzmann's thrombasthenia)

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Abstract
Patient A.F. is a 28-year-old poly transfused woman with an inherited bleeding disorder, Olanzmann's thrombasthenia. An abnormal platelet function is linked to severe decreases in the platelet content of the integrins GP IIb and GP IIIa. In 1987 the

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