Interaction of epirubicin with other cytotoxics and anti-emetic drugs

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Abstract
Epirubicin is usually administered in combination with other cytotoxics. Few pharmacological studies address whether relevant clinical Interactions occur in vitro between these drugs. This study Investigated whether epirubicin interacted with other cytotoxics or anti-emetics. The following drugs were prepared at pharmacological concentrations, etoposide (200 μg/ml), 5-fluorouracil (120 μg/ml), cisplatin (100 μg/ml), vincristine (100 μg/ml) and cyclophosphamide (1 μ/ml) respectively were admixed with epirubicin (1 μg/ml). Epirubicin was analysed by high performance liquid chromatography using in-line UV and fluorescence detectors. Experiments were performed in quadruplicate. No significant interactions were noted. The experiments were repeated for stemetil and maxoion. Maxoion did not interact with epirubicin but stemetil produced an interfering peak in the assay. We conclude that interaction studies are an Important step In the workup of chemotherapy regimens.

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