Toxic Action of Dipterex and DDVP to the House Fly1

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Abstract
Dipterex or 0,0-dilllethyll-hydroxy-2,2,2-trichlorocthyl phosphonate under mildly alkaline conditions is rapidly degraded to DDVP. The half-life values for this reaction are: pH 8.0-63 minutes, pH 7–386 minutes, and pH 6.0–89 hours. The rate of reaction is very slow at pH 5.4. The in vitro inhibition of house fly head cholinesterase by 10-7 M Dipterex showed marked pH dependency and ranged from 11% at pH 5.4 to 100% at pH 8.0, thus clearly demonstrating that DDVP formation is necessary for in vitro cholinesterase inhibition. In vivo studies of the mode of action of Dipterex showed that the rate of knockdown of house flies feeding on Dipterex-treated moist sugar bait was much more rapid at pH 7.0 than pH 5.4. This, together with the 4- to 7-fold greater toxicity of DDVP over Dipterex and the isolation of about 5% of P32 DDVP from the total P32 metabolites in Dipterex-poisoned house flies, strongly indicates that DDVP is responsible for the in vivo toxic action of Dipterex.

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