Detection of Low-Avidity Immunoglobulin G in Oral Fluid Samples: New Approach for Rubella Diagnosis and Surveillance
Open Access
- 1 January 2003
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 10 (1) , 189-190
- https://doi.org/10.1128/cdli.10.1.189-190.2003
Abstract
Low-avidity rubella immunoglobulin G (IgG) was detected in oral fluid samples from 30 of 32 rubella IgM-positive patients (sensitivity, 94%) and from 4 of 34 IgM-negative patients (specificity, 88%). Measuring IgG avidity in oral fluid samples could improve the reliability of rubella surveillance when the incidence of the disease and the positive predictive value of IgM tests are low.Keywords
This publication has 13 references indexed in Scilit:
- Rubella infection in pregnancy.1999
- Detection of Rubella Virus-Specific Immunoglobulin G in Saliva by an Amplification-Based Enzyme-Linked Immunosorbent Assay Using Monoclonal Antibody to Fluorescein IsothiocyanateJournal of Clinical Microbiology, 1999
- Salivary diagnosis of rubella: a study of notified cases in the United Kingdom, 1991–4Epidemiology and Infection, 1998
- The epidemiology of rubella in England and Wales before and after the 1994 measles and rubella vaccination campaign: fourth joint report from the PHLS and the National Congenital Rubella Surveillance Programme.1997
- Resurgence of rubellaThe Lancet, 1996
- IgG antibodies to human herpesvirus‐6 in young children: Changes in avidity of antibody correlate with time after infectionJournal of Medical Virology, 1993
- Rapid diagnosis of hantavirus disease with an IgG-avidity assayThe Lancet, 1991
- The use of antibody avidity measurements for the diagnosis of RubellaReviews in Medical Virology, 1991
- The use of saliva for viral diagnosis and screening.Epidemiology and Infection, 1988