Diazoxide in Primary Pulmonary Hypertension

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Abstract
PRIMARY pulmonary hypertension is a disease of unknown cause, predominantly occurring in young women and resulting in right ventricular failure and death in an average of seven years.1 Spontaneous regression has been reported but is rare.2 As yet, no specific treatment has been found to be effective for long-term palliation of symptoms or prevention of sudden death. We recently treated a 19-year-old girl with primary pulmonary hypertension. Injection of diazoxide into the pulmonary artery at the time of cardiac catheterization dramatically decreased pulmonary-artery pressure and resistance and markedly increased cardiac output. The patient was subsequently placed on oral diazoxide, with . . .

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