Facile formation of a cis-platin-nonapeptide complex of human DNA polymerase-? origin
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 1731-1732
- https://doi.org/10.1039/c39950001731
Abstract
cis-DDP readily forms a complex with a nonapeptide, E R F K C P C P T, selected from near the DNA binding domain of human DNA polymerase-α, through the two cysteine residues; the reaction is more than an order of magnitude faster than that for the cis-DDP and DNA reaction.Keywords
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